Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.52 |
| ▸ | SPR | P35270 | 1/20 | 0.49 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.49 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6311327 | 1.00 | CHRNB2 (0.54) | CHRNB2CHRNA4PDE3BPDE3APDE10A | |
| SCHEMBL6306245 | 1.00 | CHRNB2 (0.54) | CHRNB2CHRNA4PDE3BPDE3APDE10A | |
| SCHEMBL1936160 | 0.93 | CHRM2 (0.62) | CHRNB2CHRNA4PDE3BPDE3APDE10A | |
| SCHEMBL7237136 | 0.92 | CHRNB2 (0.55) | CHRNB2CHRNA4PDE3BPDE3APDE10A | |
| SCHEMBL7530388 | 0.92 | CHRNB2 (0.55) | CHRNB2CHRNA4PDE3BPDE3APDE10A | |
| SCHEMBL12819481 | 0.89 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 | |
| SCHEMBL7456609 | 0.85 | CHRNB1 (0.55) | CHRNB2PDE3BPDE3APDE10ACHRM2 | |
| Hydrochloric Acid SCHEMBL7461540 | 0.84 | CHRNB1 (0.54) | CHRNB2PDE3BPDE3APDE10ACHRM2 | |
| SCHEMBL6311007 | 0.82 | OGA (0.53) | CHRNB2CHRNA4PDE3BPDE3APDE10A | |
| SCHEMBL6311368 | 0.82 | CHRNB2 (0.49) | CHRNB2CHRNA4PDE3BPDE3APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3534901-B1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | UNIV VANDERBILT (US) | 2022-06-22 | — | — | EP | disclosed |