Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PTGFR | P43088 | 1/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | PTGIR | P43119 | 1/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL243735 | 0.77 | HAO1 (0.75) | HAO1MAPTKDM4EMEN1RAB9A | |
| SCHEMBL7403121 | 0.76 | SIGMAR1 (0.51) | KMT2ASIGMAR1PIK3CAPDPK1 | |
| SCHEMBL3439644 | 0.75 | HAO1 (0.84) | HAO1MAPTKDM4EMEN1RAB9A | |
| SCHEMBL316674 | 0.75 | HAO1 (0.84) | HAO1MAPTKDM4EMEN1RAB9A | |
| SCHEMBL9113934 | 0.73 | HAO1 (0.68) | HAO1MAPTKDM4EMEN1RAB9A | |
| SCHEMBL9113928 | 0.73 | HAO1 (0.68) | HAO1MAPTKDM4EMEN1RAB9A | |
| SCHEMBL4625988 | 0.71 | TRPV1 (0.47) | TBXA2RPTGER1PTGER4PTGFRPTGER3 | |
| SCHEMBL23792517 | 0.71 | TDP1 (0.59) | MEN1KMT2APYGLSIGMAR1PDPK1 | |
| SCHEMBL3197944 | 0.71 | BACE1 (0.80) | BACE1PYGL | |
| SCHEMBL3197932 | 0.71 | BACE1 (0.80) | BACE1PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189891-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-03-27 | — | — | EP | disclosed |
| WO-2001000594-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-01-04 | — | — | WO | disclosed |