Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 5/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.54 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | NMT2 | O60551 | 1/20 | 0.48 |
| ▸ | NMT1 | P30419 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7103959 | 0.95 | DRD4 (0.64) | LMNADRD4CHRNB2CHRNA4SCN8A | |
| SCHEMBL10389955 | 0.84 | CHRM2 (0.55) | LMNADRD4CHRNB2CHRNA4SCN8A | |
| SCHEMBL1875084 | 0.81 | CHRNB2 (0.62) | LMNACHRNB2CHRNA4 | |
| SCHEMBL30756757 | 0.76 | CHRNB2 (0.74) | DRD4CHRNB2CHRNA4DRD2DRD3 | |
| SCHEMBL7243314 | 0.76 | CHRNB2 (0.61) | LMNACHRNB2CHRNA4 | |
| SCHEMBL23067927 | 0.76 | CHRNB2 (0.74) | DRD4CHRNB2CHRNA4DRD2DRD3 | |
| SCHEMBL7098522 | 0.76 | CHRNB2 (0.69) | DRD4CHRNB2CHRNA4SCN8ADRD2 | |
| SCHEMBL7526151 | 0.76 | CHRNB2 (0.60) | CHRNB2CHRNA4 | |
| SCHEMBL7097610 | 0.75 | SCN8A (0.58) | DRD4CHRNB2CHRNA4SCN8ACHRM2 | |
| Hydrochloric Acid SCHEMBL11130174 | 0.75 | DRD4 (0.79) | DRD4SCN8ACHRM2DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441006-B2 | NERVOUS SYSTEM DISORDERS | TARGACEPT, INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1185513-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000071520-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2000-11-30 | — | — | WO | disclosed |