Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104124 | 0.94 | CHRNB2 (0.67) | CHRNB2CHRNA4ADRB2HTR1BNR2E1 | |
| SCHEMBL10992939 | 0.90 | CHRNB2 (0.69) | CHRNB2CHRNA4HTR1B | |
| SCHEMBL1875084 | 0.83 | CHRNB2 (0.62) | CHRNB2CHRNA4TDP1 | |
| SCHEMBL7243314 | 0.78 | CHRNB2 (0.61) | CHRNB2CHRNA4TDP1 | |
| SCHEMBL6254868 | 0.77 | CHRNB2 (0.90) | CHRNB2CHRNA4HTR1B | |
| SCHEMBL1872230 | 0.77 | CHRNB2 (0.62) | CHRNB2CHRNA4 | |
| SCHEMBL7530940 | 0.76 | LMNA (0.58) | CHRNB2CHRNA4 | |
| SCHEMBL30756567 | 0.76 | CHRNB2 (1.00) | CHRNB2CHRNA4HTR1B | |
| SCHEMBL7101352 | 0.76 | CHRNB2 (1.00) | CHRNB2CHRNA4HTR1B | |
| SCHEMBL23067927 | 0.75 | CHRNB2 (0.74) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441006-B2 | NERVOUS SYSTEM DISORDERS | TARGACEPT, INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1185513-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000071520-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2000-11-30 | — | — | WO | disclosed |