Sugi Predict

Sugi Predict / Compounds / SCHEMBL7531104

SCHEMBL7531104

SCHEMBL7531104

O=C(C=P(c1ccccc1)(c1ccccc1)c1ccccc1)C1CC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSP90AA1 P07900 1/20 0.49
▸ MEN1 O00255 4/20 0.40
▸ KMT2A Q03164 4/20 0.40
▸ MAPT P10636 2/20 0.40
▸ GAA P10253 1/20 0.40
▸ GFER P55789 1/20 0.40
▸ AKR1C3 P42330 1/20 0.38
▸ AKR1C1 Q04828 1/20 0.38
▸ ELANE P08246 1/20 0.38
▸ HTT P42858 2/20 0.37
▸ NPC1 O15118 2/20 0.37
▸ RAB9A P51151 2/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ LMNA P02545 1/20 0.37
▸ CASP3 P42574 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ SENP7 Q9BQF6 1/20 0.37
▸ HPGD P15428 1/20 0.36
▸ CA2 P00918 1/20 0.35
▸ CA4 P22748 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8059143 0.93 HSP90AA1 (0.46) HSP90AA1MEN1KMT2AGAAELANE
SCHEMBL18059140 0.91 HSP90AA1 (0.45) HSP90AA1MEN1KMT2AGAAELANE
SCHEMBL10534961 0.91 HSP90AA1 (0.45) HSP90AA1MEN1KMT2AGAAELANE
SCHEMBL20726184 0.91 HSP90AA1 (0.45) HSP90AA1MEN1KMT2AGAAELANE
SCHEMBL19424019 0.91 HSP90AA1 (0.45) HSP90AA1MEN1KMT2AGAAELANE
SCHEMBL16272178 0.91 HSP90AA1 (0.45) HSP90AA1MEN1KMT2AGAAELANE
SCHEMBL18386576 0.91 HSP90AA1 (0.45) HSP90AA1MEN1KMT2AGAAELANE
SCHEMBL21139383 0.91 HSP90AA1 (0.45) HSP90AA1MEN1KMT2AGAAELANE
SCHEMBL11008499 0.87 HSP90AA1 (0.40) HSP90AA1MEN1KMT2AMAPTGAA
SCHEMBL8618530 0.76 ALDH1A1 (0.48) HSP90AA1MEN1KMT2AGAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110156836-A A kind of preparation method of cyclopropyl carbonyl methylene triphenyl phosphorus 成家钢 2019-08-23 — — CN claimed
US-20260042765-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORP (US) 2026-02-12 — — US disclosed
US-12415809-B2 Pyrrolotriazine compounds as tam inhibitors INCYTE CORPORATION (US) 2025-09-16 — — US disclosed
US-20240124463-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORPORATION 2024-04-18 — — US disclosed
EP-4321513-A2 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS Incyte Corporation (US) 2024-02-14 — — EP disclosed
EP-3782995-B1 SPIRO CONDENSED IMIDAZOLINE-2,4-DIONE DERIVATIVES AS HISTONE ACETYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF CANCER DISEASES SHANGHAI INST MATERIA MEDICA CAS (CN) 2023-11-22 — — EP disclosed
EP-3436461-B1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORP (US) 2023-11-01 — — EP disclosed
EP-3436461-B1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORP (US) 2023-11-01 — — EP disclosed
US-11591338-B2 Pyrrolotriazine compounds as TAM inhibitors INCYTE CORPORATION (US) 2023-02-28 — — US disclosed
US-20210147430-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORPORATION 2021-05-20 — — US disclosed
CN-1274344-A Novel vitamin D analogues LEO PHARMACEUTICAL PRODUS LTD (DK) 2000-11-22 — — CN disclosed
EP-1023263-A1 NOVEL VITAMIN D ANALOGUES LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 2000-08-02 — — EP disclosed
EP-0937038-A1 VITAMIN D ANALOGUES LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 1999-08-25 — — EP disclosed
WO-1999024409-A1 ISOXAZOLE DERIVATIVES AND THEIR USE AS HERBICIDES NOVARTIS AG (CH) 1999-05-20 — — WO disclosed
WO-1999018070-A1 NOVEL VITAMIN D ANALOGUES Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1999-04-15 — — WO disclosed
WO-1998018759-A1 VITAMIN D ANALOGUES Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1998-05-07 — — WO disclosed
EP-0482100-B1 NOVEL VITAMIN D ANALOGUES LEO PHARM PROD LTD (DK) 1994-10-05 — — EP disclosed
US-5190935-A VITAMIN D ANALOGUES LEO PHARMACEUTICAL PRODUCTS LTD. (DK) 1993-03-02 — — US disclosed
WO-1991000855-A1 NOVEL VITAMIN D ANALOGUES Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1991-01-24 — — WO disclosed
EP-0227826-B1 NOVEL VITAMIN D ANALOGUES LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 1989-10-25 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260042765-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS MAP2K2, TTK, MAP2K5 HSP90AA1 3596/4885MEN1 1422/4885KMT2A 806/4885
US-20210147430-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS MERTK, MAP3K15, MAP3K5 HSP90AA1 1599/4885MEN1 1951/4885KMT2A 640/4885
US-12415809-B2 Pyrrolotriazine compounds as tam inhibitors MERTK, MAP3K15, MAP3K5 HSP90AA1 1599/4885MEN1 1951/4885KMT2A 640/4885
US-11591338-B2 Pyrrolotriazine compounds as TAM inhibitors MERTK, MAP3K15, MAP3K5 HSP90AA1 1599/4885MEN1 1951/4885KMT2A 640/4885
US-20240124463-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS MERTK, MAP3K15, MAP3K5 HSP90AA1 1599/4885MEN1 1951/4885KMT2A 640/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.