Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18386576 | 1.00 | HSP90AA1 (0.45) | HSP90AA1HPGDPOLBELANESRD5A2 | |
| SCHEMBL21139383 | 1.00 | HSP90AA1 (0.45) | HSP90AA1HPGDPOLBELANESRD5A2 | |
| SCHEMBL10534961 | 1.00 | HSP90AA1 (0.45) | HSP90AA1HPGDPOLBELANESRD5A2 | |
| SCHEMBL19424019 | 1.00 | HSP90AA1 (0.45) | HSP90AA1HPGDPOLBELANESRD5A2 | |
| SCHEMBL18059140 | 1.00 | HSP90AA1 (0.45) | HSP90AA1HPGDPOLBELANESRD5A2 | |
| SCHEMBL20726184 | 1.00 | HSP90AA1 (0.45) | HSP90AA1HPGDPOLBELANESRD5A2 | |
| SCHEMBL8059143 | 0.98 | HSP90AA1 (0.46) | HSP90AA1HPGDPOLBELANESRD5A2 | |
| SCHEMBL7531104 | 0.91 | HSP90AA1 (0.49) | HSP90AA1HPGDELANELMNAGAA | |
| SCHEMBL11008499 | 0.80 | HSP90AA1 (0.40) | HSP90AA1ALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL8618530 | 0.76 | ALDH1A1 (0.48) | HSP90AA1HPGDPOLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365558-B2 | Dihydropyridinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-14 | — | — | US | disclosed |
| US-20140357670-A1 | DIHYDROPYRIDINONE MGAT2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2014-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357670-A1 | DIHYDROPYRIDINONE MGAT2 INHIBITORS | DGAT2, DGAT1, MGAT2 | HSP90AA1 2638/4885HPGD 561/4885POLB 3290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.