SCHEMBL7531200

SCHEMBL7531200

NC(F)(CC(=O)O)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 2/20 0.53
CYP2C19 P33261 1/20 0.53
MIF P14174 1/20 0.42
PTPN1 P18031 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2D6 P10635 1/20 0.41
KCNN4 O15554 3/20 0.41
ALDH1A1 P00352 2/20 0.41
TSHR P16473 1/20 0.41
MAPT P10636 2/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA5A P35218 1/20 0.41
CA9 Q16790 1/20 0.41
KMT2A Q03164 1/20 0.41
CES1 P23141 2/20 0.39
S1PR4 O95977 1/20 0.39
LMNA P02545 1/20 0.39
S1PR1 P21453 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28110962 0.81 HIF1A (0.39) HIF1ACYP2C19PTPN1SMN1; SMN2CYP1A2
SCHEMBL637562 0.80 HIF1A (0.59) HIF1ACYP2C19MIFSMN1; SMN2CYP1A2
SCHEMBL17047062 0.80 HIF1A (0.50) HIF1ACYP2C19MIFPTPN1SMN1; SMN2
SCHEMBL17047065 0.80 HIF1A (0.50) HIF1ACYP2C19MIFPTPN1SMN1; SMN2
SCHEMBL28483320 0.78 CYP2C19 (0.57) HIF1ACYP2C19MIFPTPN1SMN1; SMN2
SCHEMBL6491100 0.78 CYP2C19 (0.57) HIF1ACYP2C19MIFPTPN1SMN1; SMN2
SCHEMBL1081533 0.78 HIF1A (0.57) HIF1ACYP2C19MIFSMN1; SMN2CYP1A2
SCHEMBL503257 0.78 MIF (0.65) HIF1ACYP2C19MIFCYP1A2KCNN4
SCHEMBL20546665 0.76 MIF (0.63) HIF1ACYP2C19MIFCYP1A2KCNN4
SCHEMBL2300536 0.75 CYP2C19 (0.64) HIF1ACYP2C19SMN1; SMN2CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1196436-A2 PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE Bristol-Myers Squibb Pharma Company (US) 2002-04-17 EP disclosed
WO-2001002424-A2 PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE DU PONT PHARMACEUTICALS COMPANY (US) 2001-01-11 WO disclosed