Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | NT5E | P21589 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | ADK | P55263 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | TYMP | P19971 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18526554 | 0.88 | ADORA3 (0.80) | ADORA3LMNATP53NT5ECA1 | |
| SCHEMBL6663776 | 0.87 | ADORA3 (0.69) | ADORA3LMNATP53NT5ECA1 | |
| SCHEMBL16160996 | 0.86 | ADORA3 (0.74) | ADORA3LMNATP53NT5ECA1 | |
| SCHEMBL6560740 | 0.82 | TYMP (0.68) | ADORA3LMNATP53ADKADORA2A | |
| SCHEMBL7197163 | 0.82 | TYMP (0.68) | ADORA3LMNATP53ADKADORA2A | |
| SCHEMBL7197169 | 0.82 | TYMP (0.68) | ADORA3LMNATP53ADKADORA2A | |
| SCHEMBL7533606 | 0.82 | RXFP1 (0.47) | ADORA3LMNATP53NT5E | |
| SCHEMBL7529814 | 0.80 | ADORA3 (0.62) | ADORA3NT5EADORA2AADORA1 | |
| SCHEMBL7529806 | 0.80 | ADORA3 (0.62) | ADORA3NT5EADORA2AADORA1 | |
| SCHEMBL4451649 | 0.80 | ADORA3 (1.00) | ADORA3NT5ECA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901499-B1 | ADENOSINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-04-10 | — | — | EP | disclosed |
| US-5998388-A | N6-PHENYL-SUBSTITUTED | GLAXO WELLCOME INC. (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0901499-A1 | ADENOSINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043300-A1 | ADENOSINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1997-11-20 | — | — | WO | disclosed |