Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463231 | 0.82 | NPSR1 (0.43) | NPSR1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL2856090 | 0.79 | IKBKB (0.45) | ALDH1A1KDM4ELMNAHPGDPDE4B | |
| SCHEMBL7823588 | 0.69 | PDE4B (0.40) | NPSR1ALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL7467767 | 0.66 | MEN1 (0.41) | NPSR1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL8011568 | 0.65 | KMT2A (0.41) | NPSR1ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL30268201 | 0.64 | NPSR1 (0.66) | NPSR1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL28039230 | 0.63 | PDE4B (0.50) | NPSR1ALDH1A1MAPTKDM4EPDE4B | |
| SCHEMBL8131195 | 0.62 | NPSR1 (0.41) | NPSR1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL458409 | 0.62 | NPSR1 (0.59) | NPSR1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL12505385 | 0.62 | BCAT2 (0.41) | NPSR1ALDH1A1MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244617-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047875-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-07-05 | — | — | WO | disclosed |