Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856090 | 0.71 | IKBKB (0.45) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7823588 | 0.69 | PDE4B (0.40) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL14447514 | 0.69 | TACR1 (0.64) | MEN1KMT2AADORA1KDM4EALDH1A1 | |
| SCHEMBL8471964 | 0.68 | ALDH1A1 (0.52) | MEN1KMT2AADORA1KDM4EALDH1A1 | |
| SCHEMBL8043766 | 0.67 | L3MBTL1 (0.52) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL22500904 | 0.66 | TOP2A (0.75) | MEN1KMT2AADORA1KDM4EALDH1A1 | |
| SCHEMBL7532137 | 0.66 | NPSR1 (0.40) | MEN1KMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7994097 | 0.65 | HDAC1 (0.48) | MEN1KMT2AALDH1A1L3MBTL1HTT | |
| SCHEMBL15845779 | 0.64 | CETP (0.43) | MEN1KMT2AADORA1KDM4EALDH1A1 | |
| SCHEMBL29037529 | 0.64 | L3MBTL1 (0.73) | MEN1KMT2AADORA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244617-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047875-A1 | SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-07-05 | — | — | WO | disclosed |