Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535261 | 0.99 | ESR1 (0.57) | ESR1ESR2KCNH2HRH3PTPN1 | |
| SCHEMBL7527322 | 0.91 | ESR1 (0.61) | ESR1ESR2ACHE | |
| SCHEMBL7533378 | 0.87 | ESR1 (0.65) | ESR1ESR2KCNH2HRH3GCGR | |
| SCHEMBL7527242 | 0.86 | ESR1 (0.66) | ESR1ESR2KCNH2HRH3GCGR | |
| SCHEMBL7530403 | 0.86 | ESR1 (0.61) | ESR1ESR2KCNH2HRH3PTPN1 | |
| SCHEMBL7528581 | 0.86 | ESR1 (0.41) | ESR1ESR2KCNH2HRH3 | |
| SCHEMBL8966126 | 0.86 | ESR1 (0.66) | ESR1ESR2KCNH2HRH3LTA4H | |
| SCHEMBL7526114 | 0.85 | ESR1 (0.63) | ESR1ESR2KCNH2HRH3PTPN1 | |
| SCHEMBL8965793 | 0.85 | ESR1 (0.68) | ESR1ESR2KCNH2HRH3LTA4H | |
| SCHEMBL8966242 | 0.85 | ESR1 (0.68) | ESR1ESR2KCNH2HRH3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832881-B1 | Benzofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0832881-A2 | Benzofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |