Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.54 |
| ▸ | CDK7 | P50613 | 4/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | WNT1 | P04628 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CLK3 | P49761 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 4/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28079206 | 0.81 | DYRK1A (0.69) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL6672160 | 0.80 | GSK3B (0.43) | DYRK1AGSK3BKCNH2 | |
| SCHEMBL6667777 | 0.80 | RAB9A (0.55) | JAK2DYRK1AWNT1GSK3BKCNH2 | |
| SCHEMBL6667774 | 0.80 | CHEK1 (0.46) | JAK2CHEK1CDK7DYRK1AGSK3B | |
| SCHEMBL17095915 | 0.77 | DYRK1A (0.82) | JAK2DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL6672697 | 0.74 | JAK2 (0.40) | JAK2CHEK1CDK7DYRK1AWNT1 | |
| SCHEMBL28775990 | 0.74 | DYRK1A (0.61) | JAK2DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL6670245 | 0.73 | FLT3 (0.40) | JAK2CHEK1CDK7DYRK1AWNT1 | |
| SCHEMBL1966636 | 0.72 | DYRK1A (0.55) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL9906854 | 0.72 | JAK2 (0.55) | JAK2CHEK1CDK7GSK3BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265873-A2 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-18 | — | — | EP | claimed |
| WO-2001070706-A2 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-09-27 | — | — | WO | claimed |
| EP-1265873-A2 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001070706-A2 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |