Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 19/20 | 0.69 |
| ▸ | WNT1 | P04628 | 9/20 | 0.69 |
| ▸ | CLK2 | P49760 | 5/20 | 0.69 |
| ▸ | CLK3 | P49761 | 5/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966636 | 0.88 | DYRK1A (0.55) | DYRK1AWNT1CLK2CLK3CDK5 | |
| SCHEMBL17096993 | 0.83 | DYRK1A (0.98) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL17095632 | 0.82 | DYRK1A (1.00) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL17096954 | 0.82 | DYRK1A (1.00) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL7532630 | 0.81 | JAK2 (0.55) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL17096358 | 0.81 | DYRK1A (0.94) | DYRK1AWNT1CLK2CLK3 | |
| SCHEMBL17096641 | 0.80 | DYRK1A (0.73) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL28079290 | 0.79 | PRKAG1 (0.48) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL13554360 | 0.78 | JAK2 (0.50) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL28087969 | 0.77 | CLK2 (0.47) | DYRK1AWNT1CLK2CLK3CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658640-A | Alkynyl alcohols and methods of use | 豪夫迈·罗氏有限公司 | 2016-06-08 | — | — | CN | disclosed |