Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19053451 | 0.75 | ALDH1A1 (0.37) | DDB1CRBNALDH1A1MAPTLMNA | |
| SCHEMBL7358825 | 0.67 | MAPT (0.49) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL22226776 | 0.66 | CHRNA7 (0.40) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL22204854 | 0.66 | CHRNA7 (0.40) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL22225733 | 0.66 | CHRNA7 (0.40) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL22204852 | 0.66 | CHRNA7 (0.40) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL21913306 | 0.65 | MEN1 (0.41) | DDB1CRBNALDH1A1MAPTLMNA | |
| SCHEMBL22204850 | 0.63 | ALDH1A1 (0.45) | ALDH1A1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL22204851 | 0.63 | ALDH1A1 (0.45) | ALDH1A1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL22828891 | 0.63 | ALDH1A1 (0.45) | ALDH1A1LMNAMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200435-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | Novartis AG (CH) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009134-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2001-02-08 | — | — | WO | disclosed |