Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 4/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22204852 | 1.00 | CHRNA7 (0.40) | CHRNA7SMN1; SMN2MEN1KMT2ACA2 | |
| SCHEMBL22225733 | 1.00 | CHRNA7 (0.40) | CHRNA7SMN1; SMN2MEN1KMT2ACA2 | |
| SCHEMBL22204854 | 1.00 | CHRNA7 (0.40) | CHRNA7SMN1; SMN2MEN1KMT2ACA2 | |
| SCHEMBL22204962 | 0.77 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2ACA2MAPT | |
| SCHEMBL22204958 | 0.77 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2ACA2MAPT | |
| SCHEMBL22225734 | 0.77 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2ACA2MAPT | |
| SCHEMBL22204960 | 0.77 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2ACA2MAPT | |
| SCHEMBL22828891 | 0.76 | ALDH1A1 (0.45) | CHRNA7SMN1; SMN2MEN1KMT2ACA2 | |
| SCHEMBL22204850 | 0.76 | ALDH1A1 (0.45) | CHRNA7SMN1; SMN2MEN1KMT2ACA2 | |
| SCHEMBL22204848 | 0.76 | ALDH1A1 (0.45) | CHRNA7SMN1; SMN2MEN1KMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986885-B1 | SUBSTITUTED PYRROLIDINE AMIDES IV | GRUENENTHAL GMBH (DE) | 2023-05-03 | — | — | EP | disclosed |
| US-20220089573-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | Grünenthal GmbH (DE) | 2022-03-24 | — | — | US | disclosed |
| WO-2020254551-A1 | SUBSTITUTED PYRROLIDINE AMIDES IV | Grünenthal GmbH (DE) | 2020-12-24 | — | — | WO | disclosed |
| US-20200223840-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | GRUENENTHAL GMBH (DE) | 2020-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200223840-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | NR3C1, NR3C2, MC2R | CHRNA7 1381/4885SMN1; SMN2 4659/4885MEN1 3553/4885 |
| US-20220089573-A1 | SUBSTITUTED PYRROLIDINE AMIDES III | NR3C1, NR3C2, MC2R | CHRNA7 1381/4885SMN1; SMN2 4659/4885MEN1 3553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.