Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7534385 | 1.00 | HTR1A (0.52) | HTR1ASLC6A4KDM4EATMKCNH2 | |
| SCHEMBL7533330 | 1.00 | HTR1A (0.52) | HTR1ASLC6A4KDM4EATMKCNH2 | |
| SCHEMBL7533383 | 0.92 | HTR1A (0.57) | HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7533386 | 0.92 | HTR1A (0.57) | HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7535111 | 0.92 | HTR1A (0.57) | HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7534471 | 0.92 | HTR1A (0.56) | HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7534465 | 0.92 | HTR1A (0.56) | HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7937558 | 0.92 | HTR1A (0.56) | HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7531345 | 0.85 | SLC6A4 (0.56) | HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7531341 | 0.85 | SLC6A4 (0.56) | HTR1ASLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228065-A1 | (INDOL-3-YL)-CYCLOALKYL]-3-SUBSTITUTED AZETIDINES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Wyeth (US) | 2002-08-07 | — | — | EP | claimed |
| US-6245799-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS; ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORP | 2001-06-12 | — | — | US | claimed |
| WO-2001034598-A1 | [(INDOL-3-YL)-CYCLOALKYL]-3-SUBSTITUTED AZETIDINES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | WYETH (US) | 2001-05-17 | — | — | WO | claimed |
| EP-1228065-A1 | (INDOL-3-YL)-CYCLOALKYL]-3-SUBSTITUTED AZETIDINES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Wyeth (US) | 2002-08-07 | — | — | EP | disclosed |
| US-6245799-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS; ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORP | 2001-06-12 | — | — | US | disclosed |
| WO-2001034598-A1 | [(INDOL-3-YL)-CYCLOALKYL]-3-SUBSTITUTED AZETIDINES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | WYETH (US) | 2001-05-17 | — | — | WO | disclosed |