Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7534465 | 1.00 | HTR1A (0.56) | HTR1AOPRM1OPRL1SLC6A4DRD2 | |
| SCHEMBL7534471 | 1.00 | HTR1A (0.56) | HTR1AOPRM1OPRL1SLC6A4DRD2 | |
| SCHEMBL7533383 | 0.92 | HTR1A (0.57) | HTR1AOPRM1OPRL1SLC6A4SLC6A2 | |
| SCHEMBL7534385 | 0.92 | HTR1A (0.52) | HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7533386 | 0.92 | HTR1A (0.57) | HTR1AOPRM1OPRL1SLC6A4SLC6A2 | |
| SCHEMBL7535111 | 0.92 | HTR1A (0.57) | HTR1AOPRM1OPRL1SLC6A4SLC6A2 | |
| SCHEMBL7533322 | 0.92 | HTR1A (0.52) | HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7533330 | 0.92 | HTR1A (0.52) | HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7534723 | 0.84 | HTR1A (0.61) | HTR1ASLC6A4SLC6A2SLC6A3HTR2A | |
| SCHEMBL7535549 | 0.84 | HTR1A (0.61) | HTR1ASLC6A4SLC6A2SLC6A3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245799-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS; ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORP | 2001-06-12 | — | — | US | claimed |
| US-6245799-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS; ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORP | 2001-06-12 | — | — | US | disclosed |