Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 16/20 | 0.61 |
| ▸ | MMP13 | P45452 | 12/20 | 0.61 |
| ▸ | MMP1 | P03956 | 10/20 | 0.61 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.61 |
| ▸ | MMP2 | P08253 | 11/20 | 0.56 |
| ▸ | MMP8 | P22894 | 6/20 | 0.56 |
| ▸ | MMP3 | P08254 | 3/20 | 0.56 |
| ▸ | MMP14 | P50281 | 2/20 | 0.56 |
| ▸ | MMP16 | P51512 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533435 | 1.00 | MMP9 (0.61) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7533681 | 0.92 | MMP9 (0.53) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7533675 | 0.92 | MMP9 (0.53) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7535677 | 0.90 | MMP13 (0.51) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7535679 | 0.90 | MMP13 (0.51) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7532087 | 0.88 | MMP9 (0.64) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7533351 | 0.88 | MMP9 (0.71) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7534926 | 0.88 | MMP13 (0.64) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7533354 | 0.88 | MMP9 (0.71) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7532082 | 0.88 | MMP9 (0.64) | MMP9MMP13MMP1ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-H1992-H1 | INHIBITION OF METALLOPROTEINASES AND TUMOR NECROSIS FACTOR CONVERTASE WHICH DEGRADE PROTEIN COMPONENTS OF EXTRACELLULAR MATRIX | AGOURON PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | claimed |
| WO-1998050348-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-12 | — | — | WO | claimed |
| US-H1992-H1 | INHIBITION OF METALLOPROTEINASES AND TUMOR NECROSIS FACTOR CONVERTASE WHICH DEGRADE PROTEIN COMPONENTS OF EXTRACELLULAR MATRIX | AGOURON PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | disclosed |
| WO-1998050348-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-12 | — | — | WO | disclosed |