Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5733112 | 0.88 | NPC1 (0.46) | RAB9ANPC1HPGDSMN1; SMN2CYP2C9 | |
| SCHEMBL7538638 | 0.87 | MAPT (0.48) | RAB9ANPC1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL5735346 | 0.81 | NPC1 (0.47) | RAB9ANPC1HPGDSMN1; SMN2CYP2C9 | |
| SCHEMBL5734241 | 0.73 | RAB9A (0.51) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL5737785 | 0.73 | NPC1 (0.51) | RAB9ANPC1HPGDSMN1; SMN2CYP2C9 | |
| SCHEMBL5737196 | 0.69 | RAB9A (0.50) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL5734481 | 0.69 | NPC1 (0.50) | RAB9ANPC1HPGDSMN1; SMN2CYP2C9 | |
| SCHEMBL6778657 | 0.69 | SNCA (0.44) | HPGDSMN1; SMN2AHRALOX15 | |
| SCHEMBL6771713 | 0.67 | LMNA (0.40) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL6772243 | 0.66 | RXFP1 (0.44) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019372-A1 | NOVEL FUSED PYRROLECARBOXAMIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1997026243-A1 | NOVEL FUSED PYRROLECARBOXAMIDES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1997-07-24 | — | — | WO | disclosed |