Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.50 |
| ▸ | QPCT | Q16769 | 2/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976857 | 0.86 | GSK3B (0.47) | GSK3BQPCTCCNE2CDK4CCND1 | |
| SCHEMBL668748 | 0.85 | CCNE2 (0.57) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL7524287 | 0.85 | CDK2 (0.44) | GSK3BQPCTCCNE2CDK4CCND1 | |
| SCHEMBL7536246 | 0.85 | CCNE2 (0.63) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| Hydrochloric Acid SCHEMBL7533156 | 0.83 | MAPT (0.47) | GSK3BQPCTCCNE2CDK4CCND1 | |
| SCHEMBL7530818 | 0.82 | GSK3B (0.58) | GSK3BQPCTPRKCA | |
| SCHEMBL7057352 | 0.81 | PRKCA (0.53) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7508119 | 0.81 | CCNE2 (0.56) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL7526686 | 0.80 | GSK3B (0.44) | GSK3BQPCTCCNE2CDK4CCND1 | |
| SCHEMBL7990839 | 0.80 | CDK2 (0.43) | GSK3BQPCTCCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | claimed |
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |