Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 13/20 | 0.45 |
| ▸ | ESR1 | P03372 | 13/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.45 |
| ▸ | TOP1 | P11387 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7541171 | 0.93 | TOP1 (0.34) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL7534973 | 0.86 | HRAS (0.43) | HRASESR1ESR2TOP1MAPT | |
| Hydrochloric Acid SCHEMBL7538326 | 0.84 | KDM4E (0.49) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL7533826 | 0.81 | HRAS (0.48) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL7533731 | 0.81 | HRAS (0.48) | HRASESR1ESR2TOP1MAPT | |
| Hydrochloric Acid SCHEMBL6178110 | 0.80 | KDM4E (0.56) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL27279001 | 0.80 | HRAS (0.47) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL27272956 | 0.80 | HRAS (0.47) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL27276235 | 0.80 | HRAS (0.47) | HRASESR1ESR2TOP1MAPT | |
| SCHEMBL27282452 | 0.80 | HRAS (0.47) | HRASESR1ESR2TOP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242374-A1 | ACRYLOYL PEPTIDIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001040181-A1 | ACRYLOYL PEPTIDIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-06-07 | — | — | WO | disclosed |