Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.34 |
| ▸ | HRAS | P01112 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533723 | 0.93 | HRAS (0.45) | TOP1HRASESR1ESR2MAPT | |
| Hydrochloric Acid SCHEMBL7538561 | 0.82 | KDM4E (0.38) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL14441803 | 0.78 | POLB (0.45) | MAPTPOLBPKMKDM4EAR | |
| SCHEMBL7541176 | 0.78 | AR (0.38) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL7534973 | 0.78 | HRAS (0.43) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL27781639 | 0.77 | POLB (0.38) | TOP1HRASESR1ESR2MAPT | |
| Hydrochloric Acid SCHEMBL7538326 | 0.76 | KDM4E (0.49) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL26374397 | 0.75 | POLB (0.43) | MAPTPOLBPKMARGAA | |
| SCHEMBL26643233 | 0.75 | HRAS (0.56) | TOP1HRASESR1ESR2MAPT | |
| SCHEMBL4348433 | 0.74 | KDM4E (0.41) | MAPTKDM4EARGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242374-A1 | ACRYLOYL PEPTIDIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001040181-A1 | ACRYLOYL PEPTIDIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-06-07 | — | — | WO | disclosed |