Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598970 | 0.92 | ALDH1A1 (0.61) | ALDH1A1KEAP1FFAR1KMT2AMEN1 | |
| SCHEMBL28508681 | 0.89 | HDAC1 (0.58) | ALDH1A1KEAP1KMT2AHDAC2HDAC8 | |
| SCHEMBL7450661 | 0.87 | ALDH1A1 (0.60) | ALDH1A1KEAP1FFAR1KMT2AMEN1 | |
| SCHEMBL19520263 | 0.87 | ALDH1A1 (0.60) | ALDH1A1KEAP1FFAR1KMT2AMEN1 | |
| SCHEMBL9888287 | 0.85 | ALDH1A1 (0.53) | ALDH1A1KEAP1FFAR1KMT2AMEN1 | |
| SCHEMBL105766 | 0.84 | ALDH1A1 (0.61) | ALDH1A1KEAP1FFAR1KMT2AMEN1 | |
| SCHEMBL691726 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KEAP1FFAR1KMT2AMEN1 | |
| SCHEMBL1822191 | 0.81 | ALDH1A1 (0.57) | ALDH1A1KEAP1FFAR1KMT2AMEN1 | |
| SCHEMBL11634237 | 0.80 | KEAP1 (0.59) | ALDH1A1KEAP1FFAR1KMT2AMEN1 | |
| SCHEMBL5247831 | 0.80 | TSHR (0.53) | KMT2AMEN1HDAC8HDAC6RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912467-B1 | ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE | RHODIA CHIMIE SA (FR) | 2002-04-24 | — | — | EP | claimed |
| CN-105611933-A | Antiproliferative compounds | GENENTECH INC | 2016-05-25 | — | — | CN | disclosed |
| EP-0071399-A2 | Substituted pyrrolidine cardiovascular system regulators and antihypertensives, their preparation and use | SYNTEX (U.S.A.) INC. (US) | 1983-02-09 | — | — | EP | disclosed |