Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GNRHR | P30968 | 7/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.36 |
| ▸ | DRD3 | P35462 | 5/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587227 | 0.96 | PARP1 (0.44) | PARP1DHODHKDM4EALDH1A1TDP1 | |
| SCHEMBL6587192 | 0.93 | PARP1 (0.50) | PARP1DHODHKDM4EGNRHRHTR1A | |
| SCHEMBL6583586 | 0.92 | PARP1 (0.51) | PARP1DHODHKDM4EALDH1A1GNRHR | |
| SCHEMBL6583719 | 0.91 | PARP1 (0.43) | PARP1DHODHKDM4EALDH1A1GNRHR | |
| SCHEMBL6590117 | 0.89 | PARP1 (0.51) | PARP1DHODHKDM4EALDH1A1PIM1 | |
| SCHEMBL6806003 | 0.89 | PARP1 (0.56) | PARP1DHODHPIM1FLT3PIM3 | |
| SCHEMBL6584782 | 0.88 | AURKA (0.46) | PARP1DHODHKDM4EALDH1A1TDP1 | |
| SCHEMBL6589815 | 0.88 | PARP1 (0.52) | PARP1DHODHKDM4EALDH1A1PIM1 | |
| SCHEMBL6587697 | 0.87 | AURKB (0.44) | PARP1DHODHKDM4EALDH1A1DRD3 | |
| SCHEMBL6799952 | 0.84 | PARP1 (0.56) | PARP1DHODHPIM1FLT3PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |