Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 4/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583719 | 0.96 | PARP1 (0.43) | AURKBPRKD3PIM1SRCFLT4 | |
| SCHEMBL6590117 | 0.93 | PARP1 (0.51) | AURKBPIM1PIM3MKNK2PARP1 | |
| SCHEMBL6589815 | 0.92 | PARP1 (0.52) | AURKBPIM1PIM3MKNK2PARP1 | |
| SCHEMBL6587227 | 0.92 | PARP1 (0.44) | AURKBPRKD3PIM1SRCFLT4 | |
| SCHEMBL6587787 | 0.90 | AURKA (0.46) | AURKBKDRPARP1AURKAALDH1A1 | |
| SCHEMBL6806262 | 0.89 | AURKB (0.57) | AURKBPRKD3PIM1SRCFLT4 | |
| SCHEMBL6587192 | 0.89 | PARP1 (0.50) | AURKBPIM1PIM3MKNK2PARP1 | |
| SCHEMBL6583586 | 0.88 | PARP1 (0.51) | AURKBPIM1PIM3MKNK2PARP1 | |
| SCHEMBL7534102 | 0.87 | PARP1 (0.43) | AURKBPIM1PIM3MKNK2PARP1 | |
| SCHEMBL6584782 | 0.86 | AURKA (0.46) | AURKBKDRPARP1AURKAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |