Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7534350 | 1.00 | TSHR (0.35) | TSHRLMNACETP | |
| SCHEMBL21536755 | 0.81 | ALDH1A1 (0.37) | TSHRLMNA | |
| SCHEMBL7522949 | 0.78 | LMNA (0.36) | TSHRLMNACETP | |
| SCHEMBL7522948 | 0.78 | LMNA (0.36) | TSHRLMNACETP | |
| SCHEMBL13395726 | 0.77 | TSHR (0.35) | TSHRCETP | |
| SCHEMBL13395740 | 0.77 | TSHR (0.35) | TSHRCETP | |
| SCHEMBL24713768 | 0.74 | TSHR (0.40) | TSHRCETP | |
| SCHEMBL15959836 | 0.74 | TSHR (0.39) | TSHRCETP | |
| SCHEMBL15354714 | 0.74 | TSHR (0.40) | TSHRCETP | |
| SCHEMBL12387829 | 0.74 | TSHR (0.40) | TSHRCETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170144971-A1 | Piperidinone Derivatives as MDM2 Inhibitors for the Treatment of Cancer | AMGEN INC. (US) | 2017-05-25 | — | — | US | disclosed |
| US-20110319378-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2011-12-29 | — | — | US | disclosed |
| EP-0842915-B1 | Optically active alcohol and process for the production thereof | MITSUBISHI GAS CHEMICAL CO (JP) | 2002-03-27 | — | — | EP | disclosed |
| EP-0842915-A2 | Optically active alcohol and process for the production thereof | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1998-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319378-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | MDM2, TP53, CDKN1A | TSHR 4432/4885LMNA 2556/4885CETP 4613/4885 |
| US-20170144971-A1 | Piperidinone Derivatives as MDM2 Inhibitors for the Treatment of Cancer | MDM2, TP53, CDKN1A | TSHR 4432/4885LMNA 2556/4885CETP 4613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.