Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.46 |
| ▸ | TUBB | P07437 | 6/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533183 | 0.91 | GAA (0.45) | GAACYP1A2CYP3A4TSHRNFKB1 | |
| SCHEMBL7537091 | 0.89 | CYP1A2 (0.47) | GAACYP1A2CYP3A4TSHRNFKB1 | |
| SCHEMBL7540460 | 0.87 | CA2 (0.49) | GAATSHRMEN1LMNAKMT2A | |
| SCHEMBL29665700 | 0.85 | TUBB1 (0.43) | LMNATUBB1 | |
| SCHEMBL7535556 | 0.85 | TUBB1 (0.43) | LMNATUBB1 | |
| SCHEMBL24458182 | 0.82 | HTT (0.41) | MEN1LMNAKMT2ATUBB1 | |
| SCHEMBL29665751 | 0.78 | TUBB1 (0.39) | LMNATUBB1 | |
| SCHEMBL24458142 | 0.78 | TUBB1 (0.39) | LMNATUBB1 | |
| SCHEMBL7533749 | 0.75 | CA12 (0.54) | MEN1LMNAKMT2A | |
| SCHEMBL7536230 | 0.75 | HTT (0.41) | LMNATUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020013496-A1 | Benzene compounds as antiproliferative and cholesterol lowering agents | AMGEN INC. | 2002-01-31 | — | — | US | claimed |
| EP-1005453-A1 | SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS | TULARIK, INC. (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1999010320-A1 | SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS | TULARIK INC. (US) | 1999-03-04 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013496-A1 | Benzene compounds as antiproliferative and cholesterol lowering agents | CYP46A1, TGFB1, NR1H2 | GAA 1364/4885CYP1A2 503/4885CYP3A4 725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.