Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7538218 | 0.86 | SIGMAR1 (0.47) | KMT2AMAP3K5MAPTMEN1 | |
| SCHEMBL8196776 | 0.79 | KDM4E (0.50) | KMT2AMAPTMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8195897 | 0.77 | DHODH (0.43) | KMT2AMAPTMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7487453 | 0.77 | DHODH (0.43) | KMT2AMAPTMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7542447 | 0.76 | KMT2A (0.42) | KMT2AMAP3K5MAPTMEN1ALDH1A1 | |
| SCHEMBL22466082 | 0.76 | MAP3K5 (0.51) | MAP3K5MAPTALDH1A1HTT | |
| SCHEMBL21954157 | 0.73 | ESR2 (0.56) | KMT2AMAP3K5MEN1 | |
| SCHEMBL30390511 | 0.73 | ESR2 (0.56) | KMT2AMAP3K5MEN1 | |
| SCHEMBL26132579 | 0.73 | ESR2 (0.56) | KMT2AMAP3K5MEN1 | |
| SCHEMBL8187218 | 0.72 | MEN1 (0.41) | KMT2AMAP3K5MAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204644-A1 | SYNTHESIS OF SUBSTITUTED AMIDINES | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2000078725-A1 | SYNTHESIS OF SUBSTITUTED AMIDINES | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |
| WO-2000078724-A2 | IMIDAZOLINDERIVATIVES THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |