Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7534836 | 0.86 | KMT2A (0.47) | MAP3K5KMT2AMEN1MAPT | |
| SCHEMBL7484801 | 0.80 | RAB9A (0.42) | SIGMAR1TMEM97DRD2DRD3KMT2A | |
| SCHEMBL7485077 | 0.72 | HRH3 (0.41) | SIGMAR1TMEM97DRD2DRD3KMT2A | |
| SCHEMBL7542447 | 0.72 | KMT2A (0.42) | MAP3K5KMT2AMEN1MAPT | |
| SCHEMBL22466082 | 0.71 | MAP3K5 (0.51) | MAP3K5MAPT | |
| SCHEMBL7481478 | 0.70 | TMEM97 (0.36) | SIGMAR1TMEM97 | |
| SCHEMBL8195562 | 0.69 | ESR1 (0.39) | SIGMAR1TMEM97MAPT | |
| SCHEMBL8196776 | 0.69 | KDM4E (0.50) | KMT2AMEN1MAPT | |
| SCHEMBL22466216 | 0.69 | MAP3K5 (0.51) | SIGMAR1TMEM97MAP3K5MAPT | |
| SCHEMBL38651001 | 0.69 | TMEM97 (0.54) | SIGMAR1TMEM97KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204644-A1 | SYNTHESIS OF SUBSTITUTED AMIDINES | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2000078725-A1 | SYNTHESIS OF SUBSTITUTED AMIDINES | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |
| WO-2000078724-A2 | IMIDAZOLINDERIVATIVES THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |