Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 7/20 | 0.62 |
| ▸ | PTGIR | P43119 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7539966 | 0.85 | NISCH (0.59) | NISCHADRA2AADRA2BADRA2CMAOA | |
| SCHEMBL7540279 | 0.82 | LMNA (0.58) | NISCHADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL7534871 | 0.82 | NISCH (0.64) | NISCHADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL8202988 | 0.79 | NISCH (0.71) | NISCHPTGIRKDM4E | |
| SCHEMBL9575256 | 0.78 | NISCH (1.00) | NISCHPTGIRKDM4E | |
| SCHEMBL24495605 | 0.75 | NISCH (0.68) | NISCHPTGIRKDM4ELMNA | |
| Hydrochloric Acid SCHEMBL8207897 | 0.73 | ADRA2A (0.47) | NISCHADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL26122325 | 0.72 | NISCH (0.76) | NISCHPTGIRKDM4EMAOAMAOB | |
| SCHEMBL11162892 | 0.71 | NISCH (0.58) | NISCHPTGIRKDM4EADRA2AADRA2B | |
| SCHEMBL6312711 | 0.71 | NISCH (0.58) | NISCHPTGIRKDM4EADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204644-A1 | SYNTHESIS OF SUBSTITUTED AMIDINES | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2000078725-A1 | SYNTHESIS OF SUBSTITUTED AMIDINES | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |
| WO-2000078724-A2 | IMIDAZOLINDERIVATIVES THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |