Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 5/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535131 | 1.00 | HDAC8 (0.49) | HDAC8OPRM1OPRD1OPRK1MMP8 | |
| SCHEMBL7536950 | 0.81 | ACE (0.49) | MMP8MMP3ALDH1A1 | |
| SCHEMBL7536956 | 0.81 | ACE (0.49) | MMP8MMP3ALDH1A1 | |
| SCHEMBL7482104 | 0.76 | HDAC8 (0.54) | HDAC8OPRM1OPRD1OPRK1MMP8 | |
| SCHEMBL7482114 | 0.76 | HDAC8 (0.54) | HDAC8OPRM1OPRD1OPRK1MMP8 | |
| SCHEMBL7980112 | 0.73 | OPRM1 (0.55) | HDAC8OPRM1OPRD1OPRK1MMP8 | |
| SCHEMBL7980051 | 0.73 | OPRM1 (0.55) | HDAC8OPRM1OPRD1OPRK1MMP8 | |
| SCHEMBL19329065 | 0.73 | PTPN1 (0.50) | HDAC8OPRM1OPRD1OPRK1MMP8 | |
| SCHEMBL12191655 | 0.72 | ACE (0.51) | MMP8MMP3ALDH1A1KDM4E | |
| SCHEMBL7473706 | 0.72 | HDAC8 (0.58) | HDAC8OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045844-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1045844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5932590-A | PEPTIDOMIMETIC IMIDAZOLYL-CONTAINING 1,2,3,4-TETRAHYDRO-QUINOLINES OR AN ANALOGOUS 3-BENZAZEPINES; ANTICARCINOGENIC AND-PROLIFERATIVE AGENTS; POLYCYSTIC KIDNEY DISEASE; RESTENOSIS PREVENTION; HEPATITIS; RETINAL VASCULARZATION | MERCK & CO., INC. (US) | 1999-08-03 | — | — | US | disclosed |
| WO-1999028314-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |