SCHEMBL7535199

SCHEMBL7535199

CC(C)OC(=O)c1cc(-c2nn(C)c(C(F)(F)F)c2Br)c(F)cc1Cl.c1ccc(-n2cccn2)cc1

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 18/20 0.37
KDM4E B2RXH2 1/20 0.35
USP2 O75604 1/20 0.35
ALDH1A1 P00352 1/20 0.35
POLB P06746 1/20 0.35
PKM P14618 1/20 0.35
ALOX15 P16050 1/20 0.35
TSHR P16473 1/20 0.35
HTT P42858 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
HSD17B10 Q99714 1/20 0.35
TRPC1 P48995 1/20 0.35
TRPC3 Q13507 1/20 0.35
STIM1 Q13586 1/20 0.35
ORAI1 Q96D31 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7561296 0.87 ALDH1A1 (0.33) ALDH1A1POLBNPSR1TRPC1TRPC3
SCHEMBL38910 0.87 ALDH1A1 (0.33) ALDH1A1POLBNPSR1TRPC1TRPC3
SCHEMBL30750946 0.87 ALDH1A1 (0.33) ALDH1A1POLBNPSR1TRPC1TRPC3
Pyrazon SCHEMBL7582671 0.82 TRPC1 (0.35) NTRK1TRPC1TRPC3STIM1ORAI1
Clopyralid SCHEMBL7589112 0.82 RIPK1 (0.34) ALDH1A1HSD17B10TRPC1TRPC3STIM1
Metazachlor SCHEMBL7583846 0.80
Difenzoquat SCHEMBL7579558 0.80 TP53 (0.34) NTRK1TRPC1TRPC3STIM1ORAI1
Tebutam SCHEMBL7580831 0.80 MEN1 (0.34) NTRK1ALDH1A1POLBTSHRNPSR1
SCHEMBL7581102 0.79 CYP3A4 (0.33) NTRK1ALDH1A1
SCHEMBL27320851 0.79 MAPT (0.34) NTRK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002057989-A2 METHOD FOR METABOLIC PROFILING BASF AKTIENGESELLSCHAFT (DE) 2002-07-25 WO disclosed