Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 8/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.52 |
| ▸ | SGK1 | O00141 | 2/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9149346 | 0.84 | KDM4E (0.56) | AXLKDM4E | |
| SCHEMBL29979783 | 0.84 | KDM4E (0.56) | AXLKDM4E | |
| Hydrochloric Acid SCHEMBL27672178 | 0.82 | KDM4E (0.55) | AXLKDM4E | |
| SCHEMBL21069147 | 0.79 | AXL (0.60) | AXLCAMKK2SGK1CLK1DYRK1A | |
| Bromide SCHEMBL21069193 | 0.77 | AXL (0.59) | AXLCAMKK2SGK1AAK1KIT | |
| SCHEMBL31024826 | 0.75 | CSNK2A1 (0.43) | AXLKDM4ECAMKK2SGK1CLK4 | |
| SCHEMBL10131672 | 0.75 | CSNK2A1 (0.49) | AXLKDM4ECAMKK2CLK2DYRK1A | |
| SCHEMBL8941778 | 0.75 | DYRK1A (0.77) | AXLCAMKK2SGK1CLK1CLK2 | |
| Sulfuric Acid SCHEMBL21069194 | 0.74 | AXL (0.55) | AXLCAMKK2SGK1KITCCNT1 | |
| SCHEMBL2814713 | 0.74 | AXL (0.47) | AXLKDM4ECAMKK2SGK1CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958297-A1 | 1-ARYL-1,8-NAPHTHYLIDIN-4-ONE DERIVATIVE AS TYPE IV PHOSPHODIESTERASE INHIBITOR | SUNTORY LIMITED (JP) | 1999-11-24 | — | — | EP | disclosed |
| WO-1999007704-A1 | 1-ARYL-1,8-NAPHTHYLIDIN-4-ONE DERIVATIVE AS TYPE IV PHOSPHODIESTERASE INHIBITOR | SUNTORY LIMITED (JP) | 1999-02-18 | — | — | WO | disclosed |