Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.60 |
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.56 |
| ▸ | SGK1 | O00141 | 4/20 | 0.55 |
| ▸ | BRAF | P15056 | 4/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | KRAS | P01116 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | ARAF | P10398 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | FECH | P22830 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL21069193 | 0.99 | AXL (0.59) | AXLCAMKK2SGK1BRAFKIT | |
| Sulfuric Acid SCHEMBL21069194 | 0.95 | AXL (0.55) | AXLCAMKK2SGK1BRAFKIT | |
| SCHEMBL20408822 | 0.90 | AXL (0.55) | AXLCAMKK2SGK1BRAFKIT | |
| SCHEMBL23541592 | 0.87 | AXL (0.52) | AXLCAMKK2SGK1BRAFKIT | |
| SCHEMBL3767957 | 0.83 | AXL (0.81) | AXLCAMKK2SGK1KITEGFR | |
| SCHEMBL858916 | 0.82 | PAK1 (0.58) | AXLCAMKK2SGK1BRAFKIT | |
| SCHEMBL857971 | 0.82 | BRAF (0.59) | AXLBRAFRIPK2ABCB11EGFR | |
| SCHEMBL23412702 | 0.82 | F7 (0.56) | AXLCAMKK2BRAFKITRIPK2 | |
| Hydrochloric Acid SCHEMBL30007736 | 0.80 | CAMKK2 (0.57) | AXLCAMKK2SGK1AAK1CLK1 | |
| SCHEMBL858089 | 0.80 | PAK1 (0.61) | AXLCAMKK2SGK1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11040027-B2 | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | HEPAREGENIX GMBH (DE) | 2021-06-22 | — | — | US | disclosed |
| EP-3478684-B1 | NEW PROCESSES FOR THE PREPARATION OF VEMURAFENIB | FERMION OY (FI) | 2020-04-15 | — | — | EP | disclosed |
| US-10407427-B2 | Processes for the preparation of Vemurafenib | FERMION OY (FI) | 2019-09-10 | — | — | US | disclosed |
| US-20190194197-A1 | NEW PROCESSES FOR THE PREPARATION OF VEMURAFENIB | FERMION OY (FI) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11040027-B2 | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | MAPK4, HNF4A, HGF | AXL 3608/4885CAMKK2 131/4885SGK1 79/4885 |
| US-10407427-B2 | Processes for the preparation of Vemurafenib | BRAF, NRAS, PDCD1 | AXL 41/4885CAMKK2 4057/4885SGK1 1627/4885 |
| US-20190194197-A1 | NEW PROCESSES FOR THE PREPARATION OF VEMURAFENIB | BRAF, RAF1, NRAS | AXL 50/4885CAMKK2 3809/4885SGK1 1652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.