Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 11/20 | 0.54 |
| ▸ | CTSS | P25774 | 9/20 | 0.54 |
| ▸ | CTSB | P07858 | 5/20 | 0.54 |
| ▸ | CTSK | P43235 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.44 |
| ▸ | GRN | P28799 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7562349 | 0.90 | CTSL (0.54) | CTSLCTSSCTSBCTSKKMT2A | |
| SCHEMBL5523605 | 0.89 | CTSL (0.53) | CTSLCTSSCTSBCTSKRAB9A | |
| SCHEMBL5522774 | 0.89 | CTSS (0.53) | CTSLCTSSCTSBCTSKNPC1 | |
| SCHEMBL7567919 | 0.89 | USP30 (0.54) | CTSLCTSSCTSBCTSKKMT2A | |
| SCHEMBL5525335 | 0.88 | CTSL (0.69) | CTSLCTSSCTSBCTSKGRN | |
| SCHEMBL5530441 | 0.88 | CTSL (0.69) | CTSLCTSSCTSBCTSKGRN | |
| SCHEMBL7539325 | 0.88 | CTSS (0.54) | CTSLCTSSCTSBCTSKNPC1 | |
| SCHEMBL5520686 | 0.88 | CTSL (0.58) | CTSLCTSSCTSBCTSKGPR132 | |
| SCHEMBL6590402 | 0.86 | CTSL (0.51) | CTSLCTSSCTSBCTSKNPC1 | |
| SCHEMBL5525443 | 0.85 | CTSL (0.55) | CTSLCTSSCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178958-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000055125-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |