Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2975777 | 0.81 | FBP1 (0.41) | FBP1NPC1RAB9AKMT2APKM | |
| SCHEMBL9305341 | 0.80 | PDPK1 (0.45) | FBP1NPC1RAB9AKMT2APKM | |
| SCHEMBL3886947 | 0.74 | MEN1 (0.50) | NPC1RAB9AKMT2APKMALDH1A1 | |
| SCHEMBL2983284 | 0.73 | FFAR1 (0.41) | FBP1NPC1RAB9AKMT2APKM | |
| SCHEMBL6798397 | 0.72 | PDPK1 (0.38) | FBP1NPC1RAB9AKMT2APKM | |
| SCHEMBL18939227 | 0.71 | LMNA (0.46) | NPC1RAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL26101042 | 0.71 | RBBP9 (0.41) | NPC1RAB9AKMT2APKMALDH1A1 | |
| SCHEMBL330278 | 0.69 | CHRM2 (0.39) | FBP1NPC1RAB9AKMT2APKM | |
| SCHEMBL4305587 | 0.68 | APP (0.44) | ALDH1A1GAAHTTPTGDR2CYP1A2 | |
| SCHEMBL4589649 | 0.65 | PDPK1 (0.63) | FBP1NPC1RAB9AKMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391894-B1 | ANTICANCER AGENTS; ANTIPROLIFERATIVE AGENTS | SMITHKLINE BEECHAM CORPORATION | 2002-05-21 | — | — | US | claimed |
| EP-1137415-A4 | MYT1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-20 | — | — | EP | claimed |
| EP-1137415-A1 | MYT1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-04 | — | — | EP | claimed |
| WO-2000033842-A1 | MYT1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-15 | — | — | WO | claimed |
| US-6391894-B1 | ANTICANCER AGENTS; ANTIPROLIFERATIVE AGENTS | SMITHKLINE BEECHAM CORPORATION | 2002-05-21 | — | — | US | disclosed |