SCHEMBL7536149

SCHEMBL7536149

CCCCCSC(=O)N(C)C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.48
CHRNB4 P30926 1/20 0.48
CHRNA3 P32297 1/20 0.48
CHRNA4 P43681 1/20 0.48
ALDH1A1 P00352 1/20 0.43
CES2 O00748 7/20 0.42
THRB P10828 2/20 0.42
GMNN O75496 1/20 0.42
TP53 P04637 1/20 0.42
POLB P06746 1/20 0.42
MAPT P10636 1/20 0.42
CYP2C9 P11712 1/20 0.42
BLM P54132 1/20 0.42
HSD17B10 Q99714 1/20 0.42
ACHE P22303 3/20 0.41
EPHX1 P07099 1/20 0.38
CES1 P23141 8/20 0.37
FAAH O00519 4/20 0.37
PLA2G6 O60733 1/20 0.37
NOS3 P29474 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15471407 0.98 CHRNB2 (0.47) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL11849588 0.93 CHRNB2 (0.50) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL11129844 0.83
SCHEMBL6687731 0.78 CES2 (0.44) ALDH1A1CES2THRBGMNNTP53
SCHEMBL38665236 0.78 CES2 (0.44) ALDH1A1CES2THRBGMNNTP53
SCHEMBL10963898 0.77 CHRNB2 (0.48) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL8412988 0.77 CHRNB2 (0.48) CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL10915008 0.75 CES2 (0.48) ALDH1A1CES2THRBGMNNTP53
SCHEMBL1016346 0.73
SCHEMBL8982128 0.73 CES2 (0.52) ALDH1A1CES2THRBGMNNTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0860433-B1 QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME KIRIN BREWERY (JP) 2002-07-03 EP disclosed
US-6143764-A ETHER DERIVATIVES OF QUINOLINE, ANTITUMOR AGENTS KIRIN BEER KABUSHIKI KAISHA (JP) 2000-11-07 US disclosed
EP-0860433-A1 QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 1998-08-26 EP disclosed
EP-0166516-B1 NOVEL PHENYL-SUBSITUTED SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-04-08 EP disclosed
EP-0212779-B1 HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-01-22 EP disclosed
US-4948416-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-14 US disclosed
US-4878937-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-11-07 US disclosed
US-4854962-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-08-08 US disclosed
US-4842639-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-06-27 US disclosed
US-4802911-A HERBICIDES, PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-02-07 US disclosed
US-4752322-A Herbicidal sulfonamides DUMAS DONALD J (US) 1988-06-21 US disclosed
US-4746356-A Herbicidal sulfonamides E. I. DUPONT DE NEMOURS AND COMPANY (US) 1988-05-24 US disclosed