SCHEMBL7536629

SCHEMBL7536629

CC(C(=O)O)C(=O)COCc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.51
NPC1 O15118 2/20 0.48
TSHR P16473 2/20 0.47
ALDH1A1 P00352 2/20 0.46
SLC1A1 P43005 3/20 0.45
GRM5 P41594 1/20 0.43
SLC15A1 P46059 1/20 0.43
SLC1A3 P43003 2/20 0.42
SLC1A2 P43004 2/20 0.42
MEN1 O00255 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
KMT2A Q03164 1/20 0.42
PTPRC P08575 1/20 0.42
PTPN1 P18031 1/20 0.42
MME P08473 1/20 0.41
RAB9A P51151 1/20 0.41
CA1 P00915 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21048734 0.87 NPC1 (0.50) MAPTNPC1TSHRALDH1A1SLC1A1
SCHEMBL10165853 0.86 TSHR (0.50) MAPTNPC1TSHRALDH1A1SLC1A1
SCHEMBL6597874 0.82 MAPT (0.48) MAPTNPC1ALDH1A1GRM5MEN1
SCHEMBL4998340 0.81 NPC1 (0.47) MAPTNPC1TSHRALDH1A1SLC1A1
SCHEMBL15932086 0.81 LMNA (0.45) MAPTNPC1TSHRALDH1A1MEN1
SCHEMBL998563 0.80 ALDH1A1 (0.60) MAPTNPC1TSHRALDH1A1SLC1A1
SCHEMBL2069896 0.80 ALDH1A1 (0.60) MAPTNPC1TSHRALDH1A1SLC1A1
SCHEMBL939537 0.80 ALDH1A1 (0.60) MAPTNPC1TSHRALDH1A1SLC1A1
SCHEMBL17677433 0.80 NPC1 (0.46) MAPTNPC1TSHRALDH1A1GRM5
SCHEMBL18114862 0.79 NPC1 (0.45) MAPTNPC1TSHRALDH1A1GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912467-B1 ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE RHODIA CHIMIE SA (FR) 2002-04-24 EP claimed
WO-2021123785-A1 DNA POLYMERASE THETA INHIBITORS ARTIOS PHARMA LIMITED (GB) 2021-06-24 WO disclosed