Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | CCR1 | P32246 | 2/20 | 0.46 |
| ▸ | CCR5 | P51681 | 2/20 | 0.46 |
| ▸ | CCR8 | P51685 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8675092 | 0.79 | ALDH1A1 (0.56) | BTKKDM4ELMNANPC1RAB9A | |
| SCHEMBL27196408 | 0.76 | KDM4E (0.54) | BTKKDM4ELMNANPC1RAB9A | |
| SCHEMBL15271337 | 0.75 | BTK (0.35) | BTKKDM4ELMNANPC1RAB9A | |
| SCHEMBL29624537 | 0.73 | KDM4E (0.62) | BTKKDM4ELMNANPC1RAB9A | |
| SCHEMBL1456454 | 0.73 | KDM4E (0.62) | BTKKDM4ELMNANPC1RAB9A | |
| SCHEMBL20510086 | 0.73 | KDM4E (0.50) | BTKKDM4ELMNANPC1RAB9A | |
| SCHEMBL1988750 | 0.73 | KDM4E (0.58) | BTKKDM4ELMNANPC1RAB9A | |
| SCHEMBL5709792 | 0.72 | NOTUM (0.52) | BTKKDM4ELMNANPC1RAB9A | |
| SCHEMBL29664837 | 0.72 | NOTUM (0.52) | BTKKDM4ELMNANPC1RAB9A | |
| SCHEMBL1456955 | 0.71 | KDM4E (0.59) | BTKKDM4ELMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4405628-A | 4-Pyridylimidazolones and method of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |