Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 15/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13279680 | 0.70 | OPRD1 (0.47) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL6440014 | 0.68 | GRIN2D (0.58) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL7476313 | 0.67 | NISCH (0.34) | — | |
| SCHEMBL29756093 | 0.66 | GRIN2D (0.59) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL5310894 | 0.66 | OPRD1 (0.64) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL5310898 | 0.66 | OPRD1 (0.64) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL13279450 | 0.66 | USP30 (0.47) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL31457501 | 0.62 | OPRD1 (0.43) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL13280082 | 0.62 | GRIN2D (0.49) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL30668686 | 0.62 | GRIN2D (0.79) | OPRD1KCNH2GRIN2DGRIN3BCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6004977-A | ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |