Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 13/20 | 0.48 |
| ▸ | MMP13 | P45452 | 12/20 | 0.48 |
| ▸ | MMP1 | P03956 | 6/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 11/20 | 0.47 |
| ▸ | MMP8 | P22894 | 9/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | MMP16 | P51512 | 1/20 | 0.47 |
| ▸ | BMP1 | P13497 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | DUT | P33316 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7537326 | 1.00 | MMP9 (0.48) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7539907 | 0.90 | MMP9 (0.48) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7539903 | 0.90 | MMP9 (0.48) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7532359 | 0.89 | MMP13 (0.48) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7532364 | 0.89 | MMP13 (0.48) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7532683 | 0.87 | MMP13 (0.51) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7532678 | 0.87 | MMP13 (0.51) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7537818 | 0.84 | MMP9 (0.62) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7537813 | 0.84 | MMP9 (0.62) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7534320 | 0.83 | MMP9 (0.53) | MMP9MMP13MMP1ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050348-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-12 | — | — | WO | claimed |
| US-H1992-H1 | INHIBITION OF METALLOPROTEINASES AND TUMOR NECROSIS FACTOR CONVERTASE WHICH DEGRADE PROTEIN COMPONENTS OF EXTRACELLULAR MATRIX | AGOURON PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | disclosed |
| WO-1998050348-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-12 | — | — | WO | disclosed |