Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 9/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.97 |
| ▸ | MAPT | P10636 | 9/20 | 0.97 |
| ▸ | RAB9A | P51151 | 7/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.97 |
| ▸ | NPC1 | O15118 | 6/20 | 0.97 |
| ▸ | GAA | P10253 | 5/20 | 0.97 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.86 |
| ▸ | VCP | P55072 | 1/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.86 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.86 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.86 |
| ▸ | RELA | Q04206 | 4/20 | 0.86 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.86 |
| ▸ | RECQL | P46063 | 1/20 | 0.86 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.84 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12297852 | 1.00 | PTGS2 (1.00) | PTGS2MEN1KMT2AMAPTRAB9A | |
| SCHEMBL12297395 | 0.94 | PTGS2 (1.00) | PTGS2MEN1KMT2AMAPTRAB9A | |
| SCHEMBL12297430 | 0.93 | PTGS2 (0.86) | PTGS2MEN1KMT2AMAPTRAB9A | |
| SCHEMBL12297264 | 0.93 | MEN1 (0.95) | PTGS2MEN1KMT2AMAPTRAB9A | |
| SCHEMBL12297423 | 0.93 | PTGS2 (0.86) | PTGS2MEN1KMT2AMAPTRAB9A | |
| SCHEMBL11375904 | 0.93 | PTGS2 (0.86) | PTGS2MEN1KMT2AMAPTRAB9A | |
| SCHEMBL12297262 | 0.93 | ALOX5 (1.00) | PTGS2MEN1KMT2AMAPTRAB9A | |
| SCHEMBL1822120 | 0.93 | MEN1 (1.00) | PTGS2MEN1KMT2AMAPTRAB9A | |
| SCHEMBL1889521 | 0.93 | PTGS2 (0.86) | PTGS2MEN1KMT2AMAPTRAB9A | |
| SCHEMBL29276782 | 0.93 | MEN1 (1.00) | PTGS2MEN1KMT2AMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391894-B1 | ANTICANCER AGENTS; ANTIPROLIFERATIVE AGENTS | SMITHKLINE BEECHAM CORPORATION | 2002-05-21 | — | — | US | claimed |
| EP-1137415-A4 | MYT1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-20 | — | — | EP | claimed |
| EP-1137415-A1 | MYT1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-04 | — | — | EP | claimed |
| WO-2000033842-A1 | MYT1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-15 | — | — | WO | claimed |
| US-6391894-B1 | ANTICANCER AGENTS; ANTIPROLIFERATIVE AGENTS | SMITHKLINE BEECHAM CORPORATION | 2002-05-21 | — | — | US | disclosed |
| EP-1137415-A4 | MYT1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-20 | — | — | EP | disclosed |
| EP-1137415-A1 | MYT1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000033842-A1 | MYT1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |