Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6658776 | 0.80 | AURKA (0.53) | ALDH1A1AURKACHEK1KEAP1NFE2L2 | |
| SCHEMBL7936537 | 0.77 | RAD52 (0.44) | ALDH1A1POLBBLMDAPK3FGFR1 | |
| SCHEMBL11318564 | 0.77 | KMT2A (0.45) | ALDH1A1POLBBLMPDPK1KDR | |
| SCHEMBL24317500 | 0.77 | CDK2 (0.44) | ALDH1A1POLBBLMCHEK1PDPK1 | |
| SCHEMBL5893941 | 0.73 | CES1 (0.53) | ALDH1A1AURKACHEK1KEAP1NFE2L2 | |
| SCHEMBL11838515 | 0.73 | KMT2A (0.38) | ALDH1A1POLBBLMCDK2KMT2A | |
| SCHEMBL10905704 | 0.72 | KMT2A (0.40) | ALDH1A1POLBBLMCDK2KMT2A | |
| SCHEMBL157601 | 0.71 | KDM4E (0.55) | ALDH1A1POLBAURKACHEK1KEAP1 | |
| SCHEMBL10865297 | 0.71 | KMT2A (0.42) | ALDH1A1POLBBLMCDK2KMT2A | |
| SCHEMBL24317498 | 0.70 | MAPT (0.43) | ALDH1A1POLBCDK2KMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769532-B1 | Naphtholactamimide fluorescent dyes | CIBA SC HOLDING AG (CH) | 2002-03-13 | — | — | EP | claimed |
| EP-0769532-B1 | Naphtholactamimide fluorescent dyes | CIBA SC HOLDING AG (CH) | 2002-03-13 | — | — | EP | disclosed |
| EP-0769532-A1 | Naphtholactamimide fluorescent dyes | Ciba SC Holding AG (CH) | 1997-04-23 | — | — | EP | disclosed |
| EP-0769532-A1 | Naphtholactamimide fluorescent dyes | Ciba SC Holding AG (CH) | 1997-04-23 | — | — | EP | disclosed |