Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8512952 | 0.90 | KMT2A (0.40) | HDAC3HDAC2CYP3A4HDAC4HDAC1 | |
| SCHEMBL15654480 | 0.85 | ENPP2 (0.39) | PDE10AKMT2AMEN1ALDH1A1PDE2A | |
| SCHEMBL3477140 | 0.78 | HDAC3 (0.47) | HDAC3HDAC2CYP3A4HDAC4HDAC1 | |
| SCHEMBL13259875 | 0.76 | HRH3 (0.37) | HDAC3HDAC2PDE10AKMT2AMEN1 | |
| SCHEMBL9994849 | 0.76 | MEN1 (0.40) | PDE10AKMT2AMEN1ALDH1A1PDE2A | |
| SCHEMBL9993048 | 0.76 | MEN1 (0.41) | PDE10AKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL13259948 | 0.75 | PDE2A (0.40) | HDAC3HDAC2PDE10AKMT2AMEN1 | |
| SCHEMBL8512363 | 0.75 | KMT2A (0.41) | KMT2AMEN1ALDH1A1RAB9ANPC1 | |
| SCHEMBL8512860 | 0.74 | RAB9A (0.36) | PDE10AKMT2AMEN1ALDH1A1PDE2A | |
| SCHEMBL8512858 | 0.74 | RAB9A (0.36) | PDE10AKMT2AMEN1ALDH1A1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2429998-A1 | 5-MEMBERED HETEROCYCLIC COMPOUND CYCLOPENTA[C]PYRROLYLALKYLCARBAMATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130943-A1 | 5-MEMBERED HETEROCYCLIC COMPOUND CYCLOPENTA[C]PYRROLYLALKYLCARBAMATE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-11-18 | — | — | WO | disclosed |