Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | AKT1 | P31749 | 8/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12571300 | 0.94 | TSHR (0.59) | TSHRCYP1A2AKT1PDPK1ABCB11 | |
| SCHEMBL11315263 | 0.79 | CYP1A2 (0.59) | TSHRCYP1A2AKT1ALDH1A1MAPT | |
| SCHEMBL94500 | 0.78 | — | — | |
| SCHEMBL5096038 | 0.73 | CYP1A2 (1.00) | TSHRCYP1A2AKT1ALDH1A1MAPT | |
| SCHEMBL11321928 | 0.73 | TSHR (0.46) | TSHRCYP1A2MAPTCA1CA2 | |
| SCHEMBL11321178 | 0.71 | CYP1A2 (0.49) | TSHRCYP1A2AKT1ALDH1A1MAPT | |
| SCHEMBL28887731 | 0.71 | PKM (0.45) | TSHRCYP1A2AKT1PDPK1ABCB11 | |
| SCHEMBL28887723 | 0.71 | AKT1 (0.44) | TSHRCYP1A2AKT1PDPK1ABCB11 | |
| SCHEMBL28887718 | 0.71 | PKM (0.42) | TSHRCYP1A2AKT1PDPK1ABCB11 | |
| SCHEMBL6275094 | 0.70 | TSHR (0.57) | TSHRCYP1A2ALDH1A1MAPTCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064273-B1 | 1,3,4-THIADIAZOLES USEFUL FOR THE TREATMENT OF CMV INFECTIONS | UPJOHN CO (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-1064273-A2 | 1,3,4-THIADIAZOLES USEFUL FOR THE TREATMENT OF CMV INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 2001-01-03 | — | — | EP | disclosed |
| US-6150385-A | VIRICIDE WITH ACTIVITY AGAINST CYTOMEGALO VIRUS (CMV), HERPES VIRUS INCLUDING VARICELLA ZOSTER VIRUS, THE EPSTEIN-BARR VIRUS, THE HERPES SIMPLEX VIRUS, AND THE HUMAN HERPES VIRUS TYPE 8 (HHV-8) | PHARMACIA & UPJOHN COMPANY (US) | 2000-11-21 | — | — | US | disclosed |
| WO-1999047507-A2 | 1,3,4-THIADIAZOLES USEFUL FOR THE TREATMENT OF CMV INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1999-09-23 | — | — | WO | disclosed |
| US-4229577-A | IMPROVED REACTIVITY, MINIMAL FOG, HIGH FASTNESS TO LIGHT | CIBA-GEIGY AG (CH) | 1980-10-21 | — | — | US | disclosed |
| US-4115121-A | TWO-EQUIVALENT BENZOYLACETANILIDE METHYLENE COUPLERS | CIBA-GEIGY AG (CH) | 1978-09-19 | — | — | US | disclosed |
| US-3728354-A | 2-PERCHLOROCROTONYLAMINO-5-TRIFLUOROMETHYL-1,3,4-THIADIAZOLE | BAYER AG | 1973-04-17 | — | — | US | disclosed |