SCHEMBL7540148

SCHEMBL7540148

CC#CCNc1nc2ccccc2o1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 9/20 0.50
RAB9A P51151 9/20 0.50
SMN1; SMN2 Q16637 5/20 0.50
PKM P14618 3/20 0.50
NPSR1 Q6W5P4 2/20 0.50
GAA P10253 2/20 0.50
ALDH1A1 P00352 1/20 0.50
MAPT P10636 3/20 0.48
HSP90AA1 P07900 1/20 0.46
PCSK9 Q8NBP7 5/20 0.45
TP53 P04637 2/20 0.45
LMNA P02545 1/20 0.44
ALOX15 P16050 1/20 0.44
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
POLB P06746 1/20 0.43
CASP6 P55212 1/20 0.43
PSMB8 P28062 1/20 0.41
ELANE P08246 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4816936 0.82 NPC1 (0.51) NPC1RAB9ASMN1; SMN2PKMNPSR1
SCHEMBL2417087 0.80 NPC1 (0.53) NPC1RAB9ASMN1; SMN2PKMNPSR1
SCHEMBL11451768 0.80 ELANE (0.61) NPC1RAB9ASMN1; SMN2PKMNPSR1
SCHEMBL18013087 0.77 ELANE (0.63) NPC1RAB9ASMN1; SMN2PKMNPSR1
SCHEMBL9234640 0.76 HDAC6 (0.45) RAB9ASMN1; SMN2ALDH1A1MAPTTP53
SCHEMBL3948639 0.75 PCSK9 (0.54) NPC1RAB9ASMN1; SMN2PKMNPSR1
SCHEMBL5021496 0.75 PCSK9 (0.59) NPC1RAB9ASMN1; SMN2PKMNPSR1
SCHEMBL9237045 0.75 HDAC6 (0.49) NPC1RAB9ASMN1; SMN2GAAMEN1
SCHEMBL18013093 0.74 ELANE (0.65) NPC1RAB9ASMN1; SMN2PKMNPSR1
SCHEMBL9234635 0.74 HDAC6 (0.48) NPC1RAB9ASMN1; SMN2GAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5518872-A HIGH SPEED COLOR FILMS, BENZOXAZOLE, BENZOTHIAZOLE, OR BENZOSELENAZOLE SENSITIZER EASTMAN KODAK COMPANY (US) 1996-05-21 US claimed
EP-0712033-B1 An improved emulsion and photographic element EASTMAN KODAK CO (US) 2002-06-05 EP disclosed
EP-0718681-A1 Silver halide emulsions containing fused dihydropyrimidines EASTMAN KODAK COMPANY (US) 1996-06-26 EP disclosed
US-5518872-A HIGH SPEED COLOR FILMS, BENZOXAZOLE, BENZOTHIAZOLE, OR BENZOSELENAZOLE SENSITIZER EASTMAN KODAK COMPANY (US) 1996-05-21 US disclosed
EP-0712033-A1 An improved emulsion and photographic element EASTMAN KODAK COMPANY (US) 1996-05-15 EP disclosed
US-5482825-A Silver halide emulsions containing fused dihydropyrimidines EASTMAN KODAK COMPANY (US) 1996-01-09 US disclosed
US-4451557-A Photographic speed increasing and latent image stabilizing compounds, silver halide emulsions, and photographic elements EASTMAN KODAK COMPANY (US) 1984-05-29 US disclosed