⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28273191 | 0.83 | LMNA (0.43) | — | |
| SCHEMBL27456739 | 0.82 | — | — | |
| SCHEMBL27989118 | 0.81 | LMNA (0.42) | — | |
| SCHEMBL106833 | 0.81 | ALDH1A1 (0.38) | — | |
| SCHEMBL10689702 | 0.80 | TSHR (0.33) | — | |
| SCHEMBL27574329 | 0.80 | TSHR (0.33) | — | |
| SCHEMBL7514006 | 0.77 | TSHR (0.35) | — | |
| SCHEMBL10913610 | 0.75 | — | — | |
| SCHEMBL7788653 | 0.74 | TSHR (0.33) | — | |
| SCHEMBL7769147 | 0.74 | TSHR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0732338-B1 | 2,2-Difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides | LILLY CO ELI (US) | 2002-05-15 | — | — | EP | disclosed |
| US-5808047-A | Process for the preparation of 2,2'-anhydro- and 2'-keto-1-(3',5'-di-O-protected-β-D-arabinofuranosyl) nucleosides | ELI LILLY AND COMPANY (US) | 1998-09-15 | — | — | US | disclosed |
| EP-0735045-A1 | Process for the preparation of 2,2'-andhydro- and 2'-keto-1-(3',5'-di-o-protected-beta -d-arabinofuranosyl) nucleosides | ELI LILLY AND COMPANY (US) | 1996-10-02 | — | — | EP | disclosed |
| EP-0732338-A1 | 2,2-Difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides | ELI LILLY AND COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |
| US-5521294-A | 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides | ELI LILLY AND COMPANY (US) | 1996-05-28 | — | — | US | disclosed |