Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3639814 | 0.76 | OPRL1 (0.37) | — | |
| SCHEMBL7113263 | 0.73 | SLC6A3 (0.41) | SLC6A3SLC6A4SLC6A2MAPTKDM4E | |
| SCHEMBL21724095 | 0.73 | SLC6A3 (0.41) | SLC6A3SLC6A4SLC6A2MAPTKDM4E | |
| SCHEMBL5240613 | 0.69 | SLC6A3 (0.58) | SLC6A3SLC6A4SLC6A2MAPTKDM4E | |
| SCHEMBL21475399 | 0.63 | SLC6A3 (0.38) | SLC6A3SLC6A4SLC6A2MAPTKDM4E | |
| SCHEMBL13512122 | 0.62 | MAPT (0.38) | SLC6A3SLC6A4SLC6A2MAPTKDM4E | |
| SCHEMBL9694982 | 0.61 | SLC6A3 (0.41) | SLC6A3SLC6A4SLC6A2MAPTKDM4E | |
| SCHEMBL9694987 | 0.61 | SLC6A3 (0.41) | SLC6A3SLC6A4SLC6A2MAPTKDM4E | |
| SCHEMBL3630843 | 0.61 | SLC6A3 (0.44) | SLC6A3SLC6A4SLC6A2MAPTKDM4E | |
| SCHEMBL11468516 | 0.61 | MAPT (0.40) | SLC6A3SLC6A4SLC6A2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255305-B1 | PSYCHOLOGICAL DISORDERS | MERCK SHARP & DOHME LIMITED (GB) | 2001-07-03 | — | — | US | claimed |
| US-5373017-A | Renin inhibitor | G. D. SEARLE & CO. (US) | 1994-12-13 | — | — | US | claimed |
| EP-1205487-A1 | Bicyclic dipeptide isosteres, their preparation and use as beta-turn mimics | Universita Degli Studi di Firenze (IT) | 2002-05-15 | — | — | EP | disclosed |
| WO-1992002521-A1 | 1-AZABICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLIC ACID COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-02-20 | — | — | WO | disclosed |