Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 2/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3419751 | 0.76 | KCNN4 (0.40) | KCNN4KIF11 | |
| SCHEMBL20340442 | 0.70 | CNR2 (0.39) | CNR2HTTADRB2 | |
| SCHEMBL6981631 | 0.68 | OPRL1 (0.40) | — | |
| SCHEMBL5172588 | 0.68 | CD274 (0.46) | TRPV3HTTADRB2 | |
| SCHEMBL6246661 | 0.67 | KIF11 (0.39) | KCNN4KIF11 | |
| SCHEMBL8260653 | 0.66 | MME (0.32) | MME | |
| SCHEMBL5219999 | 0.66 | KIF11 (0.38) | KCNN4KIF11 | |
| SCHEMBL13163124 | 0.66 | CD274 (0.44) | TRPV3 | |
| SCHEMBL648487 | 0.65 | CTSS (0.54) | HTTSMN1; SMN2ADRB2 | |
| SCHEMBL10065920 | 0.63 | KCNN4 (0.60) | KCNN4KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676960-B1 | CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS | AVENTIS PHARM PROD INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-0676960-A4 | — | — | 1995-11-15 | — | — | EP | disclosed |
| EP-0676960-A1 | CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-10-18 | — | — | EP | disclosed |
| US-5451596-A | Cycloalkyl amine bis-aryl squalene synthase inhibitors | RHONE POULENC RORER PHARMACEUTICALS INC. (US) | 1995-09-19 | — | — | US | disclosed |
| WO-1994014435-A1 | CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-07-07 | — | — | WO | disclosed |