Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.38 |
| ▸ | TOP1 | P11387 | 2/20 | 0.38 |
| ▸ | HRAS | P01112 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533731 | 0.92 | HRAS (0.48) | ARTOP1HRASESR1ESR2 | |
| SCHEMBL7533826 | 0.92 | HRAS (0.48) | ARTOP1HRASESR1ESR2 | |
| SCHEMBL14441803 | 0.83 | POLB (0.45) | ARPKMMAPTPOLBKDM4E | |
| SCHEMBL27781639 | 0.81 | POLB (0.38) | ARTOP1HRASESR1ESR2 | |
| SCHEMBL26643233 | 0.81 | HRAS (0.56) | ARTOP1HRASESR1ESR2 | |
| SCHEMBL6176129 | 0.80 | HRAS (0.53) | ARTOP1HRASESR1ESR2 | |
| SCHEMBL26374397 | 0.80 | POLB (0.43) | ARPKMMAPTPOLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL7538567 | 0.80 | KDM4E (0.41) | TOP1HRASESR1ESR2PKM | |
| SCHEMBL4348433 | 0.79 | KDM4E (0.41) | ARMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL7541171 | 0.78 | TOP1 (0.34) | ARTOP1HRASESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242374-A1 | ACRYLOYL PEPTIDIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001040181-A1 | ACRYLOYL PEPTIDIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-06-07 | — | — | WO | disclosed |